Specialization profile--Biomedical technology and electronics

This profile concentrates on the design and development of circuits and (micro-)systems for biomedical applications.

Suggested courses

BM41055	Anatomy and physiology		4 EC		details
EE4555	Active implantable biomedical microsystems		5 EC		details
ET4127	Themes in biomedical electronics		4 EC		details
ET4130	Bioelectricity		3 EC		details
ET4252	Analog integrated circuit design		4 EC		details
ET4257	Sensors and actuators		4 EC		details
ET4260	Microsystem integration		4 EC		details
ET4277	Microelectronics reliability		4 EC		details
ET4391	Advanced microelectronics packaging		3 EC		details
SC42025	Filtering and identification		6 EC		details

MSc project proposals

Some examples of thesis topics (this list is not exhaustive):

BE	[2024] 3D Printed Bioelectronics for Regenerative Medicine
	[2024] Wireless Stimulation of the Brain with Light
	[2024] Transparent Microelectrode Arrays for Neuron Recordings and Stimulation
	[2024] Organic Electrochemical Transistors for Wound Healing
	[2024] Conformable Microelectrode Arrays for Electrical Mapping of the Heart
	[2023] Current driver circuit for power-efficient neural stimulation
	[2023] Patch clamp experiments on activation behavior of cortical neurons to electrical stimulation
	[2024] Dual-Frequency Ultrasound Neuromodulation for Minimally Invasive Brain Implants [TAKEN]
	[2024] Ultrasound-guided Ultrasound Neuromodulation
	[2021] Body Coupled Communication for Microscale Implants
	[2020] Body-coupled communication to enhance IMD security
	[2022] External electronics for ultrasonically powered stimulators
	[2024] Ultrasonic theranostics - imaging and neuromodulation in the same CMOS chip.
	[2024] Smart transparent electrode array for electroceuticals
	[2022] Ultra-Flexible Active-Matrix Electrophysiology Arrays for Neural Interfacing
	[2024] Active neural interfaces for Bioelectronic Medicine (MSc project at Fraunhofer)
	[2020] A system for blood analysis of newborns using Microneedles (with Stellenbosch South Africa)
	Ex-Situ Heart Perfusion (ESHP) sensor
ECTM	Optimising RF spectroscopy for multi-layer spectrum extraction in organ-on-chip applications
	Multi-sensor integration for broadband dielectric spectroscopy of Organ-on-Chip devices
	Control electronics for soft actuator to stimulate cardiac cells in-vitro
	Wafer-level fabrication of transparent 3D microelectrode arrays
EI	Magneto-mechanical micro-antenna for implantable devices
	Conformable CMOS-based implantable array for Brain-Computer Interfaces
	Electro-optical device for ultra-low power communication
	[2023] A Programmable High-Voltage Pulser for Miniature Ultrasound Probes
	[2023] A Compact Noise-Shaping SAR ADC for Smart Ultrasound Probes
	[2023] A compact ultrasound low-noise amplifier with built-in time-gain compensation
	[2023] 3D Integration and Packaging Schemes for Smart Ultrasound Devices
	[2023] Power management circuitry for battery-powered ultrasound patches
	[2023] A transceiver ASIC for a wearable ultrasound patch
	[2023] Data reduction by mixed-signal processing of ultrasound echo signals for wearable ultrasound devices
	[2023] Shape Sensing for Flexible Ultrasound Transducer Arrays
	A system for blood analysis of newborns using Microneedles
ELCA	[2024] A Real-Time Neural Audio Denoising Chip

Thesis examples

BE	2024	Hsukang Chen	Artifact-Free Neurostimulator with Arbitrary Waveform Generation for High-Channel, High-Density Bidirectional Neural Interfaces
	2023	Yuan Lei	An Area- and Energy-Efficient Ultrasonic Pulser Based on Self-timed Stepwise Charging
		Chunyan Xue	Wearable Ultrasonic Vagus Nerve Stimulator
		Yihao Zhang	An Energy-Efficient High-Voltage Pulser for 2D Ultrasound Phased-Array Transmitters
	2021	Berend Koele	Integrating Ultrasound Neuromodulation and Imaging. A System Concept for a Non-Invasive Image-Guided Vagus Nerve Stimulator
		Aitor del Rivero Cortázar	Microelectronic design of a pseudo voltage clamp for a 0.18um CMOS-based mesoscale neural interface for intracellular in-vitro recording and stimulation
		Joey van Rijn	Near-Realtime Low Power Epileptic Seizure Detection Using ANNs
		Ishaan Ghosh	CMOS driving channel for ultrasonic neurovascular stent
		Xinyu Yang	Ultrasound Transmitter for Non-invasive Vagus Nerve Stimulation
		Emmanouil (Manos) Kandilakis	Ultra-Low Energy Time-Mode ADC with Background Calibration for Biomedical Sensing Applications
	2020	Francesc Varkevisser	A Charge Controlled Switched-Voltage Mode Neurostimulator
		Shuang Wang	An ultrasound receiver channel for vagus nerve imaging
		Asli Yelkenci	A 16-Channel CMOS Reconfigurable Recording Unit for Simultaneous In-Vitro Microelectrode Array and Current-Clamp Measurements
		Caitlin Ramsey	Safety Investigation of Millimeter Wave Radar to Monitor Vital Signs in the NICU
		Shengjie Chen	A 3-by-3 400-MHz LC microsensor array for wireless capacitive biosensing
		Gayatri Agarwal	PVT Tolerant Transconductor for Low-Voltage Highly-Selective High-Frequency Filter of MRI Front-end Receiver
		Brian Nanhekhan	PWM-based Transthoracic Bioimpedance Analyzer for Detecting Heart Failures
		Pedro Gaizka Zufiria Gerboles	An Efficacious and Safe Multichannel Neurostimulator Powered by an Ultrasonic Wireless Link
		Tim Hosman	High-density interconnect technology optimised for flexible implants
		Alberto Gancedo Reguilon	Design and Analysis of a General Purpose Biosignal Acquisition System
	2019	Anirudh Kumar Parag	ENMOS - Energy Module for Self-Sustainable Wearable Sensors
		Aurojyoti Das	Multichannel LC ADC to Record Atrial Electrograms
		Yashwanth Sai Reddy Vyza	Capacitive Microelectrode Arrays for In-Vitro Analysis of Neural Activity
		Marc Bisschop	Resistive Matching using an AC Boost Converter for Efficient Ultrasonic Wireless Power Transfer
		Koen Emmer	Analysing the performance of KHFAC nerve block stimulation parameters
		Gandhika Wardhana	A Flexible Transparent Graphene Electrode Array for Spinal Cord Stimulation in Rats
	2018	Gerard Baquer Gómez	Optimal stimulation waveform for efficacious high-frequency block of the pudendal nerve with minimized electrochemical damage: A computer simulation optimization approach
		Dieuwert Mul	Stochastic Resonance Analog-to-Digital Conversion -- 1-Bit Signal Acquisition Employing Noise
		Tim Steunebrink	Low-power low-cost readout electronics for inductive vital-sign measurements
		Minghui Liu	Passive Wireless ECoG Monitoring On Multiple Subjects
	2016	Yao Li	A 0.6V Low Noise Current Generator for Bio-Impedance Measurements in 40nm CMOS
		Qiuyang Lin	A 0.6V, 1 uW, Low-Power Low-Noise Instrumentation Amplifier for ECG/BioZ measurement in 40nm CMOS
		Samprajani Rout	Structured Electronic Design of High-Pass ∆Σ Converters and their application to cardiac signal acquisition
		Joost Kerpels	In vivo multicell inferior olivary recordings: alternative design methods for creating cheap and flexible electrode structures
	2015	Sander Fondse	SWEAT: Sleeping Wireless Energy Transfer And Trickle Charger
	2014	Jialue Wang	Design of a Boost DC-DC Converter for Energy Harvesting Applications in 40nm CMOS Process
		Menno Vastenholt	A Sub-GHz UWB Correlation Receiver for Wireless Biomedical Communication
	2013	Luis Carlos Gutierrez	Analysis and Design of MHz-range Wireless Power Transfer Systems for Implantable Devices
	2010	Mark Stoopman	A Sub-GHz UWB Pulse Generator for Wireless Biomedical Communication
		Cees-Jeroen Bes	A front-end for sensing the stimulation and response of auditory nerve cells
		Senad Hiseni	Ultra Low-Power Analog Integrated Circuits for Extracellular Action Potential Detection
	2009	Marijn Van Dongen	A versatile output stage for implantable neural stimulators
		S. Al-Ahdab	An Ultra Low Power Fully Integrated Sensor Interface IC for Pacemakers
ECTM	2022	Bram den Ouden	Design and characterization of an implantable system for shock free cardiac rhythm control
	2021	Lovro Ivančević	OoC-integrated impedance spectroscopy for blood-brain barrier integrity analysis
		Shanliang Deng	Advanced optoelectronics driver system for biomedical applications
	2020	Joshua Teye	3D Robotic Ultrasound System
		Tim de Rijk	A 3D microelectrode array to record neural activity at different tissue depths
	2019	Aoibhinn Larkin Reddington	Noninvasive Hemodynamic Monitoring: Left Ventricular Pressure-Volume Loop Reconstruction
		Roel Stortelder	Lab-on-a-chip for individual cell response to light stimulation
	2014	Berend van Meer	Design of Cytostretch Skin A human cell based stretchable, flexible and mass-producible skin tissue model for drug development
	2011	Aashini Gulati	A Micro Surgical Instrument for Age Related Macular Degeneration
		Ting Yan	Integrated water cooling for HIFU prostate ablation
	2009	N.T. Boker	Prototyping of a Stretchable Microelectrode Array for Cardiotoxicity Drug Screening
EI	2017	Yixin Shi	A Low-Power Area-Efficient SAR-Assisted Hybrid ADC for Ultrasound Imaging
		Weichen Xu	Low-Power Readout IC for a PMUT-based bladder scanner
	2014	Ludovic Rousselot	Acoustical Monitoring of Model System for Vascular Access in Haemodialysis
		Stephen Van 't Hof	In-vitro waveguide system for the detection of Escherichia coli in drain fluid after colorectal anastomotic leakage
SPS	2017	Jelimo Maswan	Multiway Component Analysis for the Removal of Far Ventricular Signal in Unipolar Epicardial Electrograms of Patients with Atrial Fibrillation
		Xuefei You	Full-Custom Multi-Compartment Synaptic Circuits in Neuromorphic Structures
		Peter Stijnman	Transceive Phase Corrected Contrast Source Inversion-Electrical Properties Tomography

Contact person

For more information about the research group, possible thesis topics, and suggestions for your ISP:

prof.dr.ir. Wouter Serdijn

Bioelectronics Group

Department of Microelectronics