MSc thesis project proposal
Volumetric photoacoustic imaging of kidney
Project outside the universityErasmus Medical Centre
Clinical problem description
The main application of this project is kidney evaluation before transplantation. Only functioning and free of injuries kidney are suitable for transplantation. First, the kidney will be inspected for presence of injuries like necrosis or fibrosis. Second, the functioning of the kidney will be evaluated by measuring blood perfusion through the kidney’s cortex. The example of the blood perfusion is shown in Fig.1.
Technical problem description
We are using the pre-clinical Vevo LAZR-X photoacoustic system (Fujifilm Visual Sonics, Toronto, Canada). It comprises a laser source in a combination with high-frequency US probe. The probe is mounted in a translational stage facilitating 3D acquisition which volume is much smaller than the volume of the kidney. An example of the 3D sub-volume is shown in Fig. 2.
Your task would be to develop a method for full volumetric reconstruction of the kidney based on small acquired sub-volumes.
 Hysi, Eno et al. “Photoacoustic imaging of kidney fibrosis for assessing pretransplant organ quality.” JCI insight vol. 5,10 e136995. 21 May. 2020, doi:10.1172/jci.insight.136995
- Get experience in PA and US imaging
o Principles of PA imaging
o Basics of B-mode US
o PA spectroscopy
- Solve a clinically relevant problem
This project is in collaboration with Gijs van Soest from Erasmus MC
- Confident user of Matlab or Python
- Understanding of medical imaging
- Being ready to read, write and code =)
prof.dr. Paddy French
Department of Microelectronics
Last modified: 2022-04-22